1.
Which of the following choices best describe what health care
institutions and physicians should do to benefit the quality of
pharmaceutical care they provide?
Prescribe drugs to patients on a cookbook basis.
B. Monitor and if necessary restrict the practice of therapeutic
substitution of drugs within the same drug classes.
C. Permanently restrict the practice of substitution of drugs
within the same class.
D. Realize the danger associated with substitution of drugs, within
the same class, that have not been tested.
E. Both A and C.
F. Both B and D.
G. Both A and D. |
2.Pharmaceutical
companies do not need to include patients from every racial and
ethnic background when conducting drug metabolism and clinical
trials for drugs that they are developing because sample size
and randomness are more important.
True
False |
3.
Race or ethnicity is a factor that changes the probability that
an individual person will respond differently to a given drug.
:
True
False
|
4.
Physicians should not be overly concerned with atypical drug responses
or unexpected side effects when they treat patients from varied
racial and ethnic backgrounds.
True
False |
| 5.
Polymorphisms are naturally occurring variants in the structures
of genes and the products they encode. Polymorphisms may influence
a drugs action by altering its pharmacokinetics (absorption, distribution,
metabolism, excretion) or pharmacodynamic (effect on the body)
properties.
True
False
|
6.
Physicians should be aware that variations in patient’s
drug response are based upon which of the following genetic
factors?
A. Age
B. Gender
C. Disease
D. A and B above but not C
E. A,B, and C above
F. None of the above
|
7.
Physicians should be aware that variations in patient’s
drug response are based upon which of the following cultural factors?
A. attitudes,
B. beliefs
C. family influence
D. A and C above, but not B
E. A,B, and C above
F. none of the above
|
8.Physicians
should be aware that variations in patient’s drug response
are based upon which of the following environmental factors?
A. climate and parasites,
B. pollutants and smoking,
C. alcohol and recreational drug use
D. B and C but not A
E. A,B, and C above
F. none of the above
|
9.Physicians
should understand that important consequences resulting from the
Human Genome Project and the genomic revolution include which
of the following?
A. direct analysis of genes themselves by determination of their
nucleotide sequences
B. the effect of the entire genome on drug behavior can now be
determined rather than the effect of the individual genes,
C. the Human Genome project has affected other scientific areas
of study but not the area of medicine yet.
D. A and B above but not C
E. None of the above
|
| 10.
Which of the following statements about individualized medicine
are true?
A. In the future, genetic
fingerprinting will be able to determine precisely the presence
of polymorphisms in genes known to be involved in drug interactions.
B. In the future drug treatment
will be individually tailored rather than race-based.
C. research in the past
few decades has uncovered significant differences among racial
and ethnic groups in the metabolism, clinical effectiveness,
and side effect profiles of therapeutically important drugs.
D. All
of the above
E. None of the above
|
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